僅用于工業應用或科學研究，不可用于人類或動物的臨床診斷或治療，非藥用. Aflibercept （VEGF Trap） is a soluble decoy Rapidly and dose-dependently elevated BP in mice and markedly impaired endothelial-dependent relaxation （EDR） and resulted in NADPH oxidases 1 （NOX1）- and NADPH oxidases 4 （NOX4）-mediated generation of ROS, decreased the activation of protein kinase B （Akt） and endothelial nitric oxide synthase （eNOS） concurrently with a reduction in nitric oxide （NO） production and elevation of ET-1 levels in mouse aortas.